In corrispondenza della progressiva riapertura delle rotte da e per l'aeroporto di Pisa, di seguito le destinazioni già operative o in prossimità di riapertura. Invitiamo i passeggeri a consultare il sito web delle compagnie aeree per informazioni e aggiornamenti sugli orari dei voli
| Destinazione | Compagnia aerea | Sito web |
| Alghero | Ryanair | www.ryanair.com |
| Amsterdam | Transavia | www.transavia.com |
| Barcellona | Vueling Airlines | www.vueling.com |
| Barcellona-Girona | Ryanair | www.ryanair.com |
| Bari | Ryanair | www.ryanair.com |
| Berlino | Ryanair | www.ryanair.com |
| Berlino Schöenefield | Ryanair | www.ryanair.com |
| Easyjet | www.easyjet.com | |
| Billund | Ryanair | www.ryanair.com |
| Brindisi | Ryanair | www.ryanair.com |
| Bristol | Easyjet | www.easyjet.com |
| Bruxelles Charleroi | Ryanair | www.ryanair.com |
| Bruxelles Zaventem | Ryanair | www.ryanair.com |
| Bucarest Otopeni | Ryanair | www.ryanair.com |
| WizzAir | www.wizzair.com | |
| Budapest | Ryanair | www.ryanair.com |
| Cagliari | Ryanair | www.ryanair.com |
| Casablanca | Air Arabia | www.airarabia.com |
| Catania | Ryanair | www.ryanair.com |
| Cefalonia | Ryanair | www.ryanair.com |
| Comiso | Ryanair | www.ryanair.com |
| Copenaghen | SAS | www.flysas.com |
| Danzica | Ryanair | www.ryanair.com |
| Dublino | Ryanair | www.ryanair.com |
| East Midlands | Ryanair | www.ryanair.com |
| Jet2.com | www.jet2.com | |
| Edinburgo | Ryanair | www.ryanair.com |
| Eindhoven | Ryanair | www.ryanair.com |
| Fez | Ryanair | www.ryanair.com |
| Fuerteventura | Ryanair | www.ryanair.com |
| Glasgow Prestwick | Ryanair | www.ryanair.com |
| Göteborg | Ryanair | www.ryanair.com |
| Gran Canaria | Ryanair | www.ryanair.com |
| Ibiza | Ryanair | www.ryanair.com |
| Isola d'Elba (Marina di Campo) | Silverair | www.flightsandtravels.ch |
| Lamezia Terme | Ryanair | www.ryanair.com |
| Leeds Bradford | Ryanair | www.ryanair.com |
| Lisbona | Ryanair | www.ryanair.com |
| Londra Gatwick | Easyjet | www.easyjet.com |
| Londra Heathrow | British Airways | www.britishairways.com |
| Londra Luton | Easyjet | www.easyjet.com |
| Londra Stansted | Ryanair | www.ryanair.com |
| Madrid | Ryanair | www.ryanair.com |
| Malta | Ryanair | www.ryanair.com |
| Manchester | Easyjet | www.easyjet.com |
| Jet2.com | www.jet2.com | |
| Ryanair | www.ryanair.com | |
| Marrakech | Ryanair | www.ryanair.com |
| Newcastle | Jet2.com | www.jet2.com |
| Olbia | Volotea | www.volotea.com |
| Palermo | Ryanair | www.ryanair.com |
| Parigi Beauvais | Ryanair | www.ryanair.com |
| Parigi Orly | Easyjet | www.easyjet.com |
| Praga | Ryanair | www.ryanair.com |
| Rodi | Ryanair | www.ryanair.com |
| Siviglia | Ryanair | www.ryanair.com |
| Tenerife | Ryanair | www.ryanair.com |
| Tirana | Air Albania | www.airalbania.com |
| Albawings | www.albawings.com | |
| WizzAir | www.wizzair.com | |
| Trapani | Ryanair | www.ryanair.com |
| Valencia | Ryanair | www.ryanair.com |
| Varsavia Modlin | Ryanair | www.ryanair.com |
